"GO OR GROW" - LINKS BETWEEN CELLULAR FUNCTION, GLUCOSE METABOLISM AND GLIOMA MICROENVIRONMENT

To "grow" or "go": TMEM16A expression as a switch between tumor growth and metastasis in SCCHN.

PURPOSE Tumor metastasis is the leading cause of death in patients with cancer. However, the mechanisms that underlie metastatic progression remain unclear. We examined TMEM16A (ANO1) expression as a key factor shifting tumors between growth and metastasis. EXPERIMENTAL DESIGN We evaluated 26 pairs of primary and metastatic lymph node (LN) tissue from patients with squamous cell carcinoma of ...

Links between metabolism and cancer.

Metabolism generates oxygen radicals, which contribute to oncogenic mutations. Activated oncogenes and loss of tumor suppressors in turn alter metabolism and induce aerobic glycolysis. Aerobic glycolysis or the Warburg effect links the high rate of glucose fermentation to cancer. Together with glutamine, glucose via glycolysis provides the carbon skeletons, NADPH, and ATP to build new cancer ce...

Correlations Between Abnormal Glucose Metabolism and Bone Mineral Density or Bone Metabolism.

BACKGROUND The aim of this meta-analysis was to explore the correlations of abnormal glucose metabolism (AGM) with bone mineral density (BMD) and bone metabolism. MATERIAL/METHODS Relevant studies were identified using computerized and manual search strategies. The included studies were in strict accordance with inclusion and exclusion criteria. Statistical analyses were conducted with the Co...

Links between temperament and behavioral function

Despite a mutual interest in disordered behavior, the psychological approaches of individual differences and behaviorism historically have had little common research or discourse. Moreover, over time, both fields independently have developed methods of assessment and treatment that—despite being broadly applicable across populations—exist only in parallel. This also is despite the facts that (1...

Endogenous Experimental Glioma Model, Links Between Glioma Stem Cells and Angiogenesis